The Relationship and Clinical Significance between P-gp and Cell Surface Differentiation Antigens in Acute Lymphoblastic Leukemia

Objective To explore the relationship and significance between P-glycoprotein and cell surface differentiation antigens in ALL.Methods FCM was used to detect the expression of P-glycoprotein and immunophenotype in 64 de novo ALL patients.Results The positive rates of P-gp,CD34 and Ly+ were 45.3%,59.4% and 31.3%,respectirely.Compared to other surface antigens,CD13(20.3%) was the common one in My+ ALL.P-gp was negative correlation with prognosis in ALL(P0.05).No statistical difference in the CR rates were found between CD34+,My+ ALL and CD34-,My-ALL(P0.05).The positive rate of CD34 in P-gp+ patients was higher than that in P-gp patients(P0.05).The CR rate in P-gp+/CD34+ patients was lower than that in P-gp-/CD34-patients(52.2% vs 90.0%).Conclusions It is suggested that the expression of P-gp possesses prognostic significance in ALL.The overexpression of Pgp is related to CD34 and ALL patients with P-gp+/CD34+ predicts a poor prognosis.