The expression level of P-glycoprotein and cell surface differentiation antigens in acute myeloid leukemia

Aim To explore the relationship and significance between P-glycoprotein(P-gp) and cell surface differentiation antigens in acute myeloid leukemiqa(AML) patients.Methods FCM was used to detect the expression of P-glycoprotein and immunophenotype in 81 de novo AML patients.Results The positive rates of P-gp,CD34 and Ly+ in 81 AML paients were 39.5%,51.9% and 22.2% respectirely.Compared to other surface antigens,CD7(12.3%) was the common one in Ly+ AML.P-gp and CD34 were negative correlation with prognosis in AML(P0.05).The CR rates between Ly+ AML and Ly-AML patients showed no significan differences(P0.05).The positive rate of CD34 in P-gp+ patients was higher than that of P-gp-patients(P0.01).The CR rate in P-gp+/CD34+ patients was lower than that of P-gp-/CD34-patients(26.1% vs 82.7%).Conclusions It is suggested that the expression of both P-gp and CD34 possesses prognostic significance in AML.The overexpression of P-gp is related to CD34 and AML patients with P-gp+/CD34+ predicts a poor prognosis.