ScholarLens Back to search
2014•PubMedRequires access

[Using mixture design to optimize preparation technology of gankeshuangqing dispersible tablets].

Fang Zhang, Han Li, Dingkun Zhang, Chao Zhang, Ming Yang, An-Yang Bao, Xiao Xiao

Open publisher page 2 citations

Abstract

OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.

About this research paper

What this paper is about

OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE: To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets. METHODS: In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used. RESULTS: The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules. CONCLUSION: The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.

Key concepts: Dissolution, Andrographolide, Baicalin, Chromatography, Materials science, Dissolution testing, Chemistry, High-performance liquid chromatography

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
[Using mixture design to optimize preparation technology of gankeshuangqing dispersible tablets]. — Research Paper | ScholarLens