The clinical application of quantitative analyse of thyroid autoantibodies in serum

Objective To evaluate the clinical values of quantitative analyses of three kinds of thyroid autoantibodies in serum.Methods 238 cases of outpatients and inpatients with thyroid diseases were collected from 2009 to 2010,divided into 3 groups according to their clinical datas.Serum anti-thyroperoxidase antibody(TPOAb),anti-thyroglobulin antibody(TGAb) and thyrotropin receptor antibody(TRAb) levels of disease groups and control group were assayed respectively,in order to investigate the changes of 3 antibodies in different thyroid diseases.Results The differences of the serum TPOAb and TGAb levels were statistically significant.The serum levels of TPOAb and TGAb with Hashimoto's thyroiditis were significantly higher than other groups,followed by the cases with Graves'disease.The level and positive rate of TRAb in serum were significantly higher in patients with Graves'disease(stage of attack) than the control group.The remission group with Graves'disease was significantly lower than it.Conclusion TPOAb and TGAb measurements are helpful in the diagnosis of Hashimoto's thyroiditis.TRAb is also useful to determin the Graves'disease,but can not reflect the thyroid function.