Clinical application of THS and thyroid autoantibodies in the diagnosis of thyroid disease

Objective To explore the value of measurement of thyroid stimulating hormone(TSH),thyroid peroxidase antibodies(TPOAb),thyroglobulin antibody(TGAb),thyroid stimulating hormone receptor antibody(TRAb) in the autoimmune thyroid disease(AITD),and to explore its value in the diagnosis of autoimmune diseases.Methods the serum levels of TSH,TPOAB,TGAB and TRAB in 30 cases of Graves′ disease(GD),32 cases of Hashimoto thyroiditis(HT),24 cases of hypothyroidism and 39 normal controls were measured by CLIA.Results the serum levels of TSH in patients with GD were significantly lower than that in the normal control,but the serum levels of tsh in patients with hypothyroidism were significantly higher than that in the normal control;the serum levels of TPOAb、TGAb in patients with GD,TH and hypothyroidism were significantly higher than that in the normal control;the serum levels of TRAb in patients with GD were significantly higher than that in TH,hypothyroidism and the normal control.Conclusion The serum TSH is very sensitive and special parameter of the function of the hypothyroidism.The comprehensive analysis of TPOAb,and TGAB might be helpful in the differential diagnosis of thyroid diseases.The serum TRAb GD disease had a higher diagnostic value as a specific marker for the diagnosis of GD disease.