2011•Chinese Journal of Health Laboratory TechnologyRequires access
Clinical significance of thyroglobulin antibodies and thyroid peroxidase antibodies in thyroid diseases
Zhongcheng Chen, Xuejun Li, Jianhua Huang, Qin Yuling
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Abstract
Objective:To evaluate the clinical significance of thyroglobulin antibodies(TgAb) and thyroid peroxidase antibodies(TPOAb) in thyroid diseases.Methods: Serum levels of TgAb and TPOAb were assayed using chemiluminescence immunoassay in 230 thyroid disease patients and 50 healthy controls.Then the differences of the two antibodies were analyzed.Results: Compared with other groups,the higest level of serum TgAb was observed in patients with Graves disease and the higest level of serum TPOAb was observed in patients with Hashimoto′s disease(P0.05).The levels of serum TgAb and TPOAb in patients with Graves disease,Hashimoto′s disease and hyperthyroidism were higher than those in the control groups(P0.01).The levels of serum TgAb and TPOAb in patients with Autoimmune Thyroid Disease(AITD) were higher than those in patients with the non-autoimmune thyroid diseases(P0.01).Conclusion: The detection of serum TgAb and TPOAb is clinically useful in diagnosis of thyroid diseases.