2012•Basic & Clinical MedicineRequires access
Expression and clinical pathology significance of P53,ki-67,galectin-3,HBME-1, 34βE12 and CK19 in papillary thyroid carcinomas
Kejie Wang
Open publisher page 0 citations
Abstract
Objective To investigate the expression of P53,ki-67,galectin-3,HBME-1,34βE12 and CK-19 in the papillary thyroid carcinomas and clinical pathology significance.Methods By s-p immunohistochemical technique,the expression of P53,ki-67,galectin-3,HBME-1,34βE12 and CK-19 was detected in 43 cases of papillary thyroid carcinomas,37 multinodular goiters,33 follicular adenomas and 17 Hashimoto's thyroiditis.Results The expression rate of P53,ki-67,galectin-3,HBME-1,34βE12 and CK19 in the papillary thyroid carcinomas was 88.37%,79.07%,88.37%,93.02%,86.05%and 95.35% respectively.The expression rate of P53,ki-67,galectin-3,HBME-1,34βE12 and CK19 in the multinodular goiters was 18.92%,29.73%,27.03%,16.22%,24.32%和5.41% respectively.Expression of P53,ki-67,galectin-3,HBME-1,34βE12 and CK-19 were obviously different in the papillary thyroid carcinomas and benign lesions(P0.01).Conclusion Combined application of immunohistochemical staining of P53,ki-67,galectin-3,HBME-1,34βE12 and CK-19 is a potential method to differentiate papillary thyroid carcinoma and benign lesions.