2010•Harbin Yike Daxue xuebaoRequires access
Expression of HBME-1,CK19,Gal-3 and Ki-67 in papillary thyroid lesions
DU Jin-rong
Open publisher page 1 citations
Abstract
Objective To investigate the usefulness of immunohistochemical expression and immunolocalization of a panel of papillary lesions of thyroid markers including HBME-1、CK19、Galectin-3 and Ki-67.Methods By manual tissue chip technique and immunochemical EnVision method,the expression of HBME-1,CK19,Galectin-3 and Ki-67 were detected in papillary lesions of thyroid,including 55 with papillary thyroid carcinoma and 81 papillary thyroid hyperplasia.Results The positive rates for HBME-1,CK19,Gal-3 and Ki-67 in the papillary thyroid carcinoma were 94.5%,98.2%,94.6%,100%,which were significantly higher than those in the papillary thyroid hyperplasia(12.3%,12.5%,9.9%,33%)(P0.05).Conclusion HBME-1、CK19、Gal-3 and Ki-67 are useful markers to distinguish the papillary thyroid carcinoma from papillary thyroid hyperplasia,especially combined application.