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2011•Chinese Journal of MisdiagnosticsRequires access

Expression and significance of PTEN in cutaneous squamous cell carcinoma

Suhua Zhang

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Abstract

Objectives To investigate the expression of PTEN in Cutaneous Squamous cell carcinoma(SCC),and to explore the effects of PTEN in SCC.Methods To detect the expression of PTEN by EliVision immunohistochemical method.The results were analyzed statistically.Results In normal control tissues,the expression rates of PTEN was 100%,While in SCC the expression rates of PTEN was 48.1%(P0.01),at the same time the staining value also decreased(P0.01);In the well differentiated SCC group,the expression rates of PTEN was 78.6%,while in the moderate differentiated and the poor differentiated group was 36.8%(P0.05);In SCC with lymph node metastasis,the expression rates of PTEN was 9.1%,While in SCC without lymph node metastasis was 58.5%(P0.01).Conclusions Decrease of PTEN seems to involve in occurrence and progression of SCC.

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What this paper is about

Objectives To investigate the expression of PTEN in Cutaneous Squamous cell carcinoma(SCC),and to explore the effects of PTEN in SCC.Methods To detect the expression of PTEN by EliVision immunohistochemical method.The results were analyzed statistically.Results In normal control tissues,the expression rates of PTEN was 100%,While in SCC the expression rates of PTEN was 48.1%(P0.01),at the same time the staining value also decreased(P0.01);In the well differentiated SCC group,the expression rates of PTEN was 78.6%,while in the moderate differentiated and the poor differentiated group was 36.8%(P0.05);In SCC with lymph node metastasis,the expression rates of PTEN was 9.1%,While in SCC without lymph node metastasis was 58.5%(P0.01).Conclusions Decrease of PTEN seems to involve in occurrence and progression of SCC.

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Available abstract

Objectives To investigate the expression of PTEN in Cutaneous Squamous cell carcinoma(SCC),and to explore the effects of PTEN in SCC.Methods To detect the expression of PTEN by EliVision immunohistochemical method.The results were analyzed statistically.Results In normal control tissues,the expression rates of PTEN was 100%,While in SCC the expression rates of PTEN was 48.1%(P0.01),at the same time the staining value also decreased(P0.01);In the well differentiated SCC group,the expression rates of PTEN was 78.6%,while in the moderate differentiated and the poor differentiated group was 36.8%(P0.05);In SCC with lymph node metastasis,the expression rates of PTEN was 9.1%,While in SCC without lymph node metastasis was 58.5%(P0.01).Conclusions Decrease of PTEN seems to involve in occurrence and progression of SCC.

Key concepts: PTEN, Immunohistochemistry, Medicine, Cancer research, Basal cell, Metastasis, Cell, Lymph node metastasis

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