The Expression and Corelationship of P105,CD105 and PTEN Protein in Cutaneous Squamous Cell

Objective To investigate the expression and its relation ship to clinicopathological characteristis of P105,CD105 and PTEN protein in cutaneous squamous cell carcinoma.Methods Expression of P105,CD105 and PTEN protein was detected in 52 SCC and 10 normal skin specimens by SP immunohistochemical technique,and then the microvessel density(MVD) marked by CD105 protein were counted by the Weidner′s method.Results The positive rate of P105 protein and the MVD smarked by CD105 were significantly higher in SCC specimen than that in normal skin.The positive rate of PTEN was significantly lower in SCC than that in normal skin.The positive rate of P105,CD105 protein was higher respectively than those in the high-middle differentiation group,The positive rate of PTEN protein was lower than those in the high-middle differentiation group in Low differentiation of SCC pecimen;A significant positive relationship was observed between the expression of P105,CD105 and significant negative relationship of PTEN protein was relation to pathologicalgrading in SCC(all P0.05).Conclusion The enhance of P105,CD105,and the decrease or negative prefix deletion of PTEN protein expression will result in the malignant transformation and proliferation,and tumour has an aggressive marks in SCC specimen.