Analysis of antibiotic resistance of extended-spectrum β-lactamases-producing Escherichia coli strains

Objective:To study the resistance of the extended-spectrum β-lactamases(ESBLs)-producing Escherichia coli(E.coli) strains and to provide basis for clinical therapy.Methods:Agar dilution method was used to determine MICs of 13 antibiotics against 63 strains of ESBLs-producing E.coli which were collected between October 2005 and June 2006 in our hospital.Results:ESBLs-producing E.coli was generally sensitive to carbopenems and piperacillin/tazobatan,while most strains were highly resistant to piperacillin and quinolones.The rate of resistance to cefepime,ceforazone/sulbactam,ceftazidime,cefoxitin,ceftaxime and ceftriaxone were 34.92%,36.51%,44.45%,55.56%,82.54% and 84.13%,respectively.Conclusions:ESBLs-producing E.coli strains are highly resistant to antibiotics in our hospital.