Antibiotic resistance of extended spectrum β-lactamases-producing Escherichia coli

OBJECTIVE To study the resistance of the extended-spectrum β-lactamases(ESBLs)-producing Escherichia coli strains and to provide basis for clinical therapy.METHODS Agar dilution method was used to determine MICs of 13 antibiotics against 210 strains of ESBLs-producing E.coli which were collected between Jan 2008 and Dec 2008 in our hospital.RESULTS ESBLs-producing E.coli was generally sensitive to carbopenems and piperacillin/tazobatan,while most strains were highly resistant to piperacillin.The rate of resistance to cefepime,ceforazone/sulbaetam,cefiazidime,cefoxitin,ceflaxime and ceflriaxone were 32.38%,38.57%,33.33%,86.19% and 86.67%,respectively.CONCLUSION ESBLs-producing E.coli strains are highly resistant to antibiotics in our hospital.