The expression of PCNA and CD44V6 in nasopharyngeal carcinoma and their relationship

Objective: To investigate the expression of PCNA and CD44v6 in nasopharyngeal carcinoma (NPC) and their relationship. Methods: the expression of PCNA and CD44v6 were detected in 23 cases chronic nasopharyngitis and 62 NPCs (38 cases with lymph node metastases) by S-P immunohistochemical method. Results: The positive expression rates of PCNA and CD44V6 were 69.3% and 77.4% in 65 NPCs,showing statistical difference from those of 23 cases chronic nasopharyngitis (P 0.05). The positive expression rates of PCNA in metastasis group and non-metastasis group were 68.4%,70.8%, there was no statistical significance (P0.05); The positive expression rates of CD44v6 in metastasis group and non-metastasis group were 89.4%,58.3%,there was statistical significance (P0.05). PCNA and CD44V6 were expressed positively in 39 cases,while being expressed negatively in 10 cases, showing positive correlation between them (r=0.436, P0.01). Conclusion: PCNA and CD44v6 is high expression in NPCs, playing important roles in the occurrence and development of NPC.