Relationship Between Expression of uPA,PAI-1 and Microvessel Density and Invasiveness of Primary Invasive Breast Cancer

Objective:To detect the expression of uPA(urokinase plasminogen activator)、PAI-1(plasminogen activator inhibitor type 1) and angiogenesis in breast cancer and their relationship with the invasiveness of breast cancer.Methods:Eighty surgically resected breast cancer samples and twenty breast benign tumor samples were selected.S-P immunostaining technique was used to detect the expression of uPA、PAI-1and MVD in all of the tissues.Results:The positive expression rates of uPA、PAI-1 in breast cancer was significantly higher than that in the breast benign tumors,and their high expression rates were related with the clinical pathology parameters of the breast cancer(P0.05).MVD were respectively 30.87±7.64,20.28±8.72 in breast cancer and breast benign tumor group.There was significantly difference between the two groups(P0.01).There were positive correlations between the level of uPA and PAI-1 in breast cancer(P0.05).Conclusion:The expression of uPA and PAI-1 correlated with the invasiveness and metastasis of breast cancer,and they could be used as biological indicators that evaluate the invasiveness and metastasis,estimate prognosis and determine treatment of primary invasive breast cancer.