2012•Zhongguo renshougonghuanbing zazhiRequires access

Efficacy of protection effect induced by inactivated rabies vaccine(Hep-Flury-dG)

Shi Hehe, Weike Song, Huang YongLiang, Xiangyin Liu, Yuanyuan Dai, Qiuling Fu, Zhang Ying, Yingyi Lin, Yang Youtian, Xu Xiao-juan, Wang Yi-fei, Xiaofeng Guo

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Abstract

In order to determine the efficacy of inactivated rabies vaccine(Hep-Flury-dG) strain,we carried out an expending experiment in a village of Guangzhou.The information of all the dogs vaccinated in this research was collected.On day 0 before immunization and day 21 post-immunization,the blood samples of 66 dogs were collected.The serum were separated and the antibody against rabies virus were detected by ELISA.Results showed that seroconversion were 26% before using the inactivated vaccine,while was 83% after immunization.Statistical analysis indicated that there was statistical significance between antibody levels before and after immunization.The gender of the dog was not a factor that could affect the antibody level,while the age was the key factor.Thus,the inactivated rabies vaccine could offer protection against rabies virus from dog's immune system.

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What this paper is about

In order to determine the efficacy of inactivated rabies vaccine(Hep-Flury-dG) strain,we carried out an expending experiment in a village of Guangzhou.The information of all the dogs vaccinated in this research was collected.On day 0 before immunization and day 21 post-immunization,the blood samples of 66 dogs were collected.The serum were separated and the antibody against rabies virus were detected by ELISA.Results showed that seroconversion were 26% before using the inactivated vaccine,while was 83% after immunization.Statistical analysis indicated that there was statistical significance between antibody levels before and after immunization.The gender of the dog was not a factor that could affect the antibody level,while the age was the key factor.Thus,the inactivated rabies vaccine could offer protection against rabies virus from dog's immune system.

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Available abstract

In order to determine the efficacy of inactivated rabies vaccine(Hep-Flury-dG) strain,we carried out an expending experiment in a village of Guangzhou.The information of all the dogs vaccinated in this research was collected.On day 0 before immunization and day 21 post-immunization,the blood samples of 66 dogs were collected.The serum were separated and the antibody against rabies virus were detected by ELISA.Results showed that seroconversion were 26% before using the inactivated vaccine,while was 83% after immunization.Statistical analysis indicated that there was statistical significance between antibody levels before and after immunization.The gender of the dog was not a factor that could affect the antibody level,while the age was the key factor.Thus,the inactivated rabies vaccine could offer protection against rabies virus from dog's immune system.

Key concepts: Rabies, Seroconversion, Rabies vaccine, Immunization, Virology, Duck embryo vaccine, Rabies virus, Inactivated vaccine

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