Preventive effect of pancreatic stent placement for post-ERCP pancreatitis and hyperamylasemia in high-risk patients

[Objective]To investigate the preventive effect of pancreatic stent placement on post-ERCP pancreatitis(PEP) and hyperamylasemia.[Methods]We retrospectively analyzed the 123 patients with high-risk PEP between March 2006 and June 2012.The patients were divided into stent placement group(n=53) and non-stent placement group(n=70).PEP and hyperamylasemia were diagnosed according to Cotton standard.Preoperative and 6-hours-postoperative serum amylase levels were obtained.Occurrence of PEP and hyperamylasemia and prognosis were assessed.The high-risk factors influencing PEP were analyzed.[Results]Serum amylase levels before ERCP of both groups were normal.The serum amylase level of stent placement 6 hours after surgery was [(357.7±198.3)U/L],which was lower than that of non-stent placement group [(484.7±376.9)U/ L](P0.05).The incidence of PEP of stents placement group(24.5%) was lower than that of control group(55.7%)(P0.05).Post-ERCP hyperamylasemia incidence of stents placement(40.2%)was higher than that of the control group(20.0%)(P0.05).[Conclusion]Pancreatic stents placement after ERCP can effectively reduce the incidence of PEP and reduce amylase levels of patients with hyperamylasemia.