Therapeutic effects of sequential mechanical ventilation on 48 COPD patients with severe respiratory failure

Objective:To evaluate the efficacy of sequential non-invasive following invasive mechanical ventilation in COPD pa-tients with severe respiratory failure.Methods:Forty-eight COPD patients with severe respiratory failure were studied.After controlling pulmonary infection,24 patients(sequential treatment group A)were extubated and treated by non-invasive mechanical ventilation,24 cas-es(invasive ventilation group B)were kept treating by invasive mechanical ventilation and weaned by PSV mode.The duration of invasive mechanical ventilation,total mechanical ventilaiton,hospitalization and care,the incidence of ventilator associated pneumonia were com-pared between two groups.Results:For treatment group and control group,the incidence of ventilator associated pneumonia was 4.16%(1 case) vs 37.50%(9 cases)(P0.05),the total duration of mechanical ventilation was(9.32±1.87)d vs(15.36±2.16)d(P0.05) and the dura-tion of hospitalization was(15.85±2.72)d vs(25.12±3.12)d(P0.05) respectively.Conclusion:Sequential non-invasive following invasive mechanical ventilation after pulmonary infection control may significantly shorten the duration of mechanical ventilation and hospitaliza-tion,reduce medical expense and the frequency of ventilator associated pneumonia,and enhance the rescue success rate.