Analysis of chromosome abnormality in 261 couples with aderverse pregnancy outcome history in Guangzhou

Objective:To explore the types of chromosome abnormality in the couples with aderverse pregnancy outcome history.Method:Cytogenetic analysis with G-staining method was performed on the peripheral blood lymphocyte cultures of 261 couples with abnormal pregnancy-labor history.Results: Chromosome abnormalities were found in 80 patients,including 9 of reciprocal translocation,1 mosaic Turner syndrome,70 of chromosome heteromorphism which included 10 of small pericentric inversion of chromosome 9,16 of increase in length of heterochromatin on long arm of chromosomes,36 of increase/decrease in satellite length or double satellites on short arms of chromosomes in D and G groups,and 8 of increase/decrease in length of Y chromosome.Conclusion:The chromosome abnormalities of the couples with adverse pregnancy outcome history are mainly balanced reciprocal translocations and chromosome heteromorphism,and the high incidence of the latter in such couples suggests that it has some clinical effects.