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2010•Xiandai shengwu yixue jinzhanRequires access

Karyotype analysis on couples with recurrent spontaneous abortion

Fang Cao, Yu Sun Bin, Xiaoqing Zhang, Jing Wang, Xiaoyan Wu, Huang RuiPing

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Abstract

Objective: To analyze the incidence of abnormal karyotypes and clinical value of chromosome analysis in spontaneous abortion.Methods: Chromosome analysis was performed on 1018 couples who were diagnosed spontaneous abortion in January 1996 ～ June 2010.Results: 129 abnormal karotypes were detected in 1018 cases(12.67%),including 24 cases of balanced reciprocal translocation and 12 cases of Robertsonian translocations;80 cases of chromosome polymorphism;11 cases of inversions and 2 cases of duplication.Conclusion: Chromosome abnormality is one of the important factors of miscarriage and stillbirth.It is significant to analyze chromosomal in patients with early recurrent spontaneous abortion.

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What this paper is about

Objective: To analyze the incidence of abnormal karyotypes and clinical value of chromosome analysis in spontaneous abortion.Methods: Chromosome analysis was performed on 1018 couples who were diagnosed spontaneous abortion in January 1996 ～ June 2010.Results: 129 abnormal karotypes were detected in 1018 cases(12.67%),including 24 cases of balanced reciprocal translocation and 12 cases of Robertsonian translocations;80 cases of chromosome polymorphism;11 cases of inversions and 2 cases of duplication.Conclusion: Chromosome abnormality is one of the important factors of miscarriage and stillbirth.It is significant to analyze chromosomal in patients with early recurrent spontaneous abortion.

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Available abstract

Objective: To analyze the incidence of abnormal karyotypes and clinical value of chromosome analysis in spontaneous abortion.Methods: Chromosome analysis was performed on 1018 couples who were diagnosed spontaneous abortion in January 1996 ～ June 2010.Results: 129 abnormal karotypes were detected in 1018 cases(12.67%),including 24 cases of balanced reciprocal translocation and 12 cases of Robertsonian translocations;80 cases of chromosome polymorphism;11 cases of inversions and 2 cases of duplication.Conclusion: Chromosome abnormality is one of the important factors of miscarriage and stillbirth.It is significant to analyze chromosomal in patients with early recurrent spontaneous abortion.

Key concepts: Chromosomal translocation, Abortion, Karyotype, Miscarriage, Robertsonian translocation, Chromosomal Abnormality, Chromosome analysis, Chromosome abnormality

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