2012•Hainan yixueRequires access
Effect of early enteral nutrition on postoperative rehabilitation and immune function in patients with gastric cancer
Zhang Cheng-hu
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Abstract
Objective To investigate the effect of early enteral nutrition on postoperative rehabilitation and immune function in patients with gastric cancer. Methods Ninety patients of gastric cancer undergoing radical surgery were randomly divided into two groups. The study group (n=45) was treated with enteral nutrition group, while the control group (n=45) was treated with postoperative parenteral nutrition. All the patients were given appropriate care during treatment. The peripheral blood CD3+, CD4+, CD8+ and NK cell activity were determined by flow cytometry one day before surgery, one day and 7 days after surgery. The postoperative exhaust time and length of hospital stay were observed. Results The activity of CD3+, CD4+, CD4+/CD8+ and NK immune cells decreased significantly one day after treatment, with no statistically significant difference between the two groups. Seven days after treatment, the immune cell activity in the study group recovered to the preoperative level, while that in the control group was significantly lower than the preoperative (P0.05). Postoperative exhaust time and length of hospital stay were (1.8±0.5) days and (10.8±2.3) days in the study group, (2.5±0.6) days and (15.6±4.2) days in the control group, with statistically significant difference between the two groups (P0.05) Conclusion Early enteral nutrition plays an important role in the postoperative rehabilitation of gastric cancer patients after radical surgery, which helps recover the intestinal function, improve nutrition, and promote immune function.