Prevention of HBV Transmission from Mother to Infant by Injecting HBIG to Pregnant Women with Positive HBsAg

Objective To investigate the effect of passive immunization of fetus by injection of HBIG to mothers for prevention of HBV intrauterine infection. Methods Fifty-six pregnant women with positive HBsAg were divided into two groups: group A(40 cases) was injected with HBIG for many times since 28 weeks after pregnancy; group B(16 cases) was followed up without injection of HBIG as control. The blood samples of mothers and their infants were tested with ELISA and PCR. Results Among 40 infants in group A, 37 (92.5%) were positive for anti-HBs, while 2 infants in group B (12.5%) were positive for anti-HBs (P0.01).The infants with HBsAg positive and HBV DNA positive in group A were fewer than those in group B. The tite of HBsAg and level of HBV DNA were obviously descended after injection among pregnant women in group A. Conclusion Passive immunization of fetus by injection to mother with HBsAg may prevent HBV intrauterine infection effectively.