Study on the preventive effect of HBIG injection in pregnant women with HBsAg on intrauterine infection of HBV

Objective: To study the effect of passive immunization of fetus by injection of mother with HBIG on preventing HBV intrauterine infection.Methods:Ninty-six pregnant women with HBsAg positive was treated with HBIG 200 IU every month from week 28,59 cases without HBsAg as control.HBV intrauterine infetion was studied by detecting HBsAg and HBV DNA in newborns before HBIG injection in 24 hours after birth.Analyse the HBV intrauterine infection rate between the 2 groups,and also among the different injection times.Results:Rate of HBV intrauterine infection,HBsAg positive and HBV DNA positive in HBIG injection group were lower than control,but there was significant difference.Dividing the HBIG injection number of times into three groups 0～1,2～3 and 4～5,with it′s increasing.Rate of HBV intrauterine infection,HBsAg positive and HBV DNA positive was decreasing,there was but there was significant difference.Conclusion:The intrauterine infection of HBV could be possibly decreased by HBIG injection and increasing injection number of times during pregnancy.