Clinical analysis and study of preventing maternal-neonatal transmission by muscle injection with immunoglobulin of B hepatitis to surface antigen pregnant woman

Objective To investigate the effect of passive immunization of fetus by infection of mother with HBIG on drevention of HBV intrauterine infection. Methods Forty-eight pregnant women with HBsAg positive were divided into two groups:group A(68 cases)were injected with HBIG during pregnancy;group B(28 cases)were followed up without injecfion of HBIG as controls. The blood samples of mothers and their infants were tested with radioimmunoassay and PCR. Results of 70 infants in group A,64(91.46%)were positive for anti-HBs(P＜0.05).The infants with HbsAg positive and HBV DNA positive in group A were fewer than those in group B(P=0.02 and ＜0.05). Conclusions Passive immunization of fetus by iniection to mother with HBsAg may prevent HBV intrauterine infection effectively. Key words: HBV ;  HbsAg ;  Anti-HBs antibody ;  Passive immunization ;  Intrauterine infection ;