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Expression of CD147, E-cadherin and their significance in human renal carcinoma tissues microarrays

Ke Man

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Abstract

Objective To test the expression and their clinical significance of CD147 and E-cadherin in human renal cell carcinoma(RCC) tissues microarrays. Methods Eighty-two cases specimen were used to determine CD147and E- cadherin expression by immunohistochemistry. Results The expression rates of CD147 and E-cadherin were 70.7%(58/82) and 37.8%(31/82). The expression rate of CD147 was significantly higher than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). The expression rate of E-cadherin was significantly lower than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). Conclusion Re-expression of CD147 and E-cadherin is observed in human RCC, CD147 and E-cadherin may be play a crucial stage in development of human RCC. The high expression of CD147 may be a factor of poor clinical prognosis in patients with RCC.

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Objective To test the expression and their clinical significance of CD147 and E-cadherin in human renal cell carcinoma(RCC) tissues microarrays. Methods Eighty-two cases specimen were used to determine CD147and E- cadherin expression by immunohistochemistry. Results The expression rates of CD147 and E-cadherin were 70.7%(58/82) and 37.8%(31/82). The expression rate of CD147 was significantly higher than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). The expression rate of E-cadherin was significantly lower than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). Conclusion Re-expression of CD147 and E-cadherin is observed in human RCC, CD147 and E-cadherin may be play a crucial stage in development of human RCC. The high expression of CD147 may be a factor of poor clinical prognosis in patients with RCC.

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Available abstract

Objective To test the expression and their clinical significance of CD147 and E-cadherin in human renal cell carcinoma(RCC) tissues microarrays. Methods Eighty-two cases specimen were used to determine CD147and E- cadherin expression by immunohistochemistry. Results The expression rates of CD147 and E-cadherin were 70.7%(58/82) and 37.8%(31/82). The expression rate of CD147 was significantly higher than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). The expression rate of E-cadherin was significantly lower than that in 26 cases of corresponding autologous normal kinder tissues(P0.01). Conclusion Re-expression of CD147 and E-cadherin is observed in human RCC, CD147 and E-cadherin may be play a crucial stage in development of human RCC. The high expression of CD147 may be a factor of poor clinical prognosis in patients with RCC.

Key concepts: Medicine, Cadherin, Tissue microarray, Immunohistochemistry, Renal cell carcinoma, Stage (stratigraphy), Clinical significance, Carcinoma

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