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2014•Zhonghua shiyan waike zazhiRequires access

Expression of Cadherin-6 mRNA and its clinical significance in peripheral blood of patients with renal cell carcinoma

Liekui Fang, Qian Yuan, Xingli Jiang, Xiangjiang Huang, Jiansheng Huang, Xing Xiong

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Abstract

Objective To investigate the expression of Cadherin-6 mRNA and its clinical significance in peripheral blood of patients with renal cell carcinoma (RCC).Methods The expression of Cadherin-6 mRNA in 30 cases of RCC and 15 normal controls was detected by reverse transcription-polymerase chain reaction (RT-PCR).Results The positive rate of Cadherin-6 mRNA was 46.7％ in peripheral blood of RCC patients,significantly higher than in normal controls (0) (P ＜ 0.001).The expression of Cadherin-6 mRNA was increased with the increase of clinicopathologic stage.Conclusion The expression of Cadherin-6 mRNA in peripheral blood of patients with RCC is a sensitive indicator by RT-PCR. Key words: Renal cell carcinomas;  Gene diagnosis;  Cadherin-6

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Objective To investigate the expression of Cadherin-6 mRNA and its clinical significance in peripheral blood of patients with renal cell carcinoma (RCC).Methods The expression of Cadherin-6 mRNA in 30 cases of RCC and 15 normal controls was detected by reverse transcription-polymerase chain reaction (RT-PCR).Results The positive rate of Cadherin-6 mRNA was 46.7％ in peripheral blood of RCC patients,significantly higher than in normal controls (0) (P ＜ 0.001).The expression of Cadherin-6 mRNA was increased with the increase of clinicopathologic stage.Conclusion The expression of Cadherin-6 mRNA in peripheral blood of patients with RCC is a sensitive indicator by RT-PCR. Key words: Renal cell carcinomas;  Gene diagnosis;  Cadherin-6

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Available abstract

Objective To investigate the expression of Cadherin-6 mRNA and its clinical significance in peripheral blood of patients with renal cell carcinoma (RCC).Methods The expression of Cadherin-6 mRNA in 30 cases of RCC and 15 normal controls was detected by reverse transcription-polymerase chain reaction (RT-PCR).Results The positive rate of Cadherin-6 mRNA was 46.7％ in peripheral blood of RCC patients,significantly higher than in normal controls (0) (P ＜ 0.001).The expression of Cadherin-6 mRNA was increased with the increase of clinicopathologic stage.Conclusion The expression of Cadherin-6 mRNA in peripheral blood of patients with RCC is a sensitive indicator by RT-PCR. Key words: Renal cell carcinomas;  Gene diagnosis;  Cadherin-6

Key concepts: Messenger RNA, Renal cell carcinoma, Cadherin, Peripheral blood, Reverse transcription polymerase chain reaction, Clinical significance, Pathology, Peripheral

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Expression of Cadherin-6 mRNA and its clinical significance in peripheral blood of patients with renal cell carcinoma — Research Paper | ScholarLens