Changes of cellular immune function in Lewis mice with lung cancer after Shenglingbaizhusan decoction treatment

Objective: To study effects of Shenglingbaizhusan decoction on cellular immune function of Lewis mice with lung cancer.Methods: Forty Lewis mice with cancer were randomly divided into model group A,B,C and D,which were administrated with saline,Shenglinbaizhu decoction,Cisplatin and Shenglinbaizhu decoction Cisplatin,respectively,all for 12 days.Then mice were sacrificed for sample collection.Tumor growth curve were drawn,and inhibition rate of tumor,assay lymphocyte proliferation capacity were calculated,activity of NK cell in the mouse spleen,the IL-10,γ-interferon in the supernatant fluid of spleen,the rated of CD4+,CD8+ and the ratio of CD4+/CD8+ in the spleens of mice were also detected.Results: The inhibited effectiveness of group D was optimal comparing with group C and group B(P0.01).The activity of NK cell in group B was obvious higher than that of group A,C and D(P0.01).The content of IFN-Y in group B was higher than that in group C(P0.05).The content of IL-10 was the highest in group A,and the lowest in group B(P0.05).The figure of CD4+ and the ratio of CD4+/CD8+ in group B were higher than that in group A and C(P0.01).While the percentage of CD8+ cell in all groups had no obvious changes.Conclusion: Shenglingbaizhusan decoction can inhibit tumor growth and improve the cellular immune function through raising the level of IFN-Y,reducing the superior expression of IL-10,strengthening the activity of the NK cell,obviously elevating the percentage of the CD4+ cell and the ratio of CD4+/CD8+