Protective Effect of KangAiZengXiao Decoction on Immunological Deficit Rats With Implanted Tumor

Objective To study the effect mechanism of anticancer synergic (KangAiZengXiao,KAZX) decoction on gastric cancer in immunologic deficit rats with implanted tumor. Methods Forty rats were divided into normal control group(n=10), model group(n=15) and KAZX treating group(n=15). Model group and KAZX group were subcutaneously injected axillary the left upper limb with 0 5ml gastri cancer cells,MGC-803 cell(1×10 7/ml) after irradiated by 60 Co(dose:10Gy). Then the three groups were treated with KAZX decoction or distilled water every day, respectively. After three weeks, the rats were sacrificed,and blood WBC, the weight of spleen, activity of NK cell and transformation efficiency of lymphocyte were also detected.Results The rate of loaded tumor in KAZX group was significantly lower than in model group(20% vs 66 7%,P0 05). But the blood WBC ,the weight of spleen, activity of NK cell and transformation efficiency of lymphocyte of KAZX group were remarkably higher than those of the model group(P0 05 or P0 01).Conclusions KAZX decoction could depress the growth of tumor , improve the immunological function of injured rats and decreased the toxicity and side effect of 60 Co.