ScholarLens Back to search
2011•Shiyong zhongliu zazhiRequires access

Expression of E2F-1 and p27 in colorectal adenocarcinoma and its significance

Shi Zhimin

Open publisher page 0 citations

Abstract

Objective To investigate the expression of E2F-1 and p27 in colorectal adenocarcinoma and its significance.Methods The expression of E2F-1 and p27 was detected by immunohistochemical SP method in 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma.Results The positive expression ratio of E2F-1 in esophageal carcinoma was much higher than that in colorectal mucosa and colorectal adenoma(P0.05) .The expression of p27 was decreased from normal colorectal mucosa,colorectal adenoma to colorectal carcinoma(P0.05) .The expression of E2F-1 and p27 was closely correlated with the tumor differentiation,TNM classification and lymph nodes metastasis(P0.05) .Conclusion E2F-1 and p27 are closely associated with colorectal adenocarcinoma,which indicates that these two proteins might be used as biological markers for colorectal adenocarcinoma.

About this research paper

What this paper is about

Objective To investigate the expression of E2F-1 and p27 in colorectal adenocarcinoma and its significance.Methods The expression of E2F-1 and p27 was detected by immunohistochemical SP method in 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma.Results The positive expression ratio of E2F-1 in esophageal carcinoma was much higher than that in colorectal mucosa and colorectal adenoma(P0.05) .The expression of p27 was decreased from normal colorectal mucosa,colorectal adenoma to colorectal carcinoma(P0.05) .The expression of E2F-1 and p27 was closely correlated with the tumor differentiation,TNM classification and lymph nodes metastasis(P0.05) .Conclusion E2F-1 and p27 are closely associated with colorectal adenocarcinoma,which indicates that these two proteins might be used as biological markers for colorectal adenocarcinoma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the expression of E2F-1 and p27 in colorectal adenocarcinoma and its significance.Methods The expression of E2F-1 and p27 was detected by immunohistochemical SP method in 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma.Results The positive expression ratio of E2F-1 in esophageal carcinoma was much higher than that in colorectal mucosa and colorectal adenoma(P0.05) .The expression of p27 was decreased from normal colorectal mucosa,colorectal adenoma to colorectal carcinoma(P0.05) .The expression of E2F-1 and p27 was closely correlated with the tumor differentiation,TNM classification and lymph nodes metastasis(P0.05) .Conclusion E2F-1 and p27 are closely associated with colorectal adenocarcinoma,which indicates that these two proteins might be used as biological markers for colorectal adenocarcinoma.

Key concepts: Colorectal adenoma, Colorectal adenocarcinoma, Colorectal cancer, Medicine, Immunohistochemistry, Adenoma, Adenocarcinoma, E2F

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of E2F-1 and p27 in colorectal adenocarcinoma and its significance — Research Paper | ScholarLens