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Expression of the E2F-1 and eIF-4E in Colorectal Adenocarcinoma and Its Significance

He Yan

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Abstract

Objective To study the expression of E2F-1 and eIF-4E in human colorectal adenocarcinoma and its significance.Methods The immunohistochemical SP method were detected 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma with E2F-1 and eIF-4E.Results The positive expression rate of E2F-1 and eIF-4E in esophageal carcinoma was much higher than that in colorectal mucosa,colorectal polyps,colorectal adenoma(P0.05).The expression of E2F-1 and eIF-4E was closely correlated with the differentiation,TNM and lymph nodes metastasis(P0.05).Conclusion E2F-1 and eIF-4E is closely related to the colorectal adenocarcinoma occurrence.Both of them are important biological markers in colorectal adenocarcinoma occurrence and development.

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What this paper is about

Objective To study the expression of E2F-1 and eIF-4E in human colorectal adenocarcinoma and its significance.Methods The immunohistochemical SP method were detected 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma with E2F-1 and eIF-4E.Results The positive expression rate of E2F-1 and eIF-4E in esophageal carcinoma was much higher than that in colorectal mucosa,colorectal polyps,colorectal adenoma(P0.05).The expression of E2F-1 and eIF-4E was closely correlated with the differentiation,TNM and lymph nodes metastasis(P0.05).Conclusion E2F-1 and eIF-4E is closely related to the colorectal adenocarcinoma occurrence.Both of them are important biological markers in colorectal adenocarcinoma occurrence and development.

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Available abstract

Objective To study the expression of E2F-1 and eIF-4E in human colorectal adenocarcinoma and its significance.Methods The immunohistochemical SP method were detected 78 cases of colorectal adenocarcinoma,20 cases of normal colorectal mucosa and 30 cases of colorectal adenoma with E2F-1 and eIF-4E.Results The positive expression rate of E2F-1 and eIF-4E in esophageal carcinoma was much higher than that in colorectal mucosa,colorectal polyps,colorectal adenoma(P0.05).The expression of E2F-1 and eIF-4E was closely correlated with the differentiation,TNM and lymph nodes metastasis(P0.05).Conclusion E2F-1 and eIF-4E is closely related to the colorectal adenocarcinoma occurrence.Both of them are important biological markers in colorectal adenocarcinoma occurrence and development.

Key concepts: Medicine, Colorectal adenocarcinoma, Colorectal adenoma, Colorectal cancer, Adenocarcinoma, Immunohistochemistry, Internal medicine, E2F

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Expression of the E2F-1 and eIF-4E in Colorectal Adenocarcinoma and Its Significance — Research Paper | ScholarLens