Control study of multislice CT perfusion in hepatocellular carcinoma

Objective To study the parameters of multislice CT (MSCT) perfusion of hepatocellular carcinoma (HCC). Methods Dynamic CT with singe location sequences CT scan of the liver was obtained in 23 individuals, including 10 control subjects and 13 patients with HCC proven by clinic. Liver perfusion parameters such as total hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT), permeability of capillary vessel surface (PS) and hepatic arterial index (HAI) were calculated, and the change of the hemodynamic was estimated. Results Compared with the control group, HAI (0.19±0.06 versus 0.58±0.20, P =0.000) and HBF [(131.31±38.25) ml/(100 ml·min) versus (344.52± 95.42 ) ml/(100 ml·min), P =0.002] in HCC group increased significantly, and MTT [(12±2) s versus (8±4) s, P = 0.028 ] decreased significantly. HBV [(27.49±11.48) ml/100 ml versus (28.67±16.81) ml/100 ml, P =0.913] and PS [(28.09±15.50) ml/(100 ml·min) versus (31.36±23.98) ml/(100 ml·min), P =0.678] did not differ between the two groups. Conclusion Hepatic perfusion parameters measured with CT were significantly altered in HCC. Perfusion CT could be a new method to evaluate the blood supply of tumor.