2007•Chinese Journal of Laboratory DiagnosisRequires access

Effects of aprotinin on Lipid Peroxidation of Mice Acute Liver Injury Induced by carbon tetrachloride

Yingyu Zhang

Abstract

Objective To investigate the effect of aprotinin on lipid peroxidation of mice acute liver injury induced by carbon tetrachloride.Methods The acute hepatic injury model of mice were induced by carbon tetrachloride(CCl4).Measuringthe changes of activity of serum superoxide dismutase(SOD),malondialdehyde(MDA),glutathioe(GSH),Observing the pathologic change of liver tissue.Results Aprotinin could increase the activities of serum SOD,GSH and decrease the lever of serum MAD.Aprotinin could improve the pathologic change of liver tissue of acute hepatic injury significantly.Conclusion Aprotinin has protective functions on mice with acute liver injury on lipid peroxidation.

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Key concepts: Aprotinin, Lipid peroxidation, Carbon tetrachloride, Malondialdehyde, Pharmacology, Liver injury, Superoxide dismutase, Chemistry