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2005•Chinese Journal of Laboratory DiagnosisRequires access

Protective Effect of aprotinin Agaist Acute Hepatic Injury in Mice

Chang Shu-fang

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Abstract

Objective To investigate the protective effect of aprotinin agaist acute hepatic injury in Mice. Methods The acute hepatic injury model of mice were induced by carbon tetrachloride(CCl_4). Measuring the changes of activity of serum ALT, AST and malondialdehyde(MDA) content of liver tissue, Observing the pathologic change of liver tissue. Results Aprotinin could decrease the activities of serum ALT, AST and the MAD content of liver tissue. Aprotinin could improve the pathologic change of liver tissue of acute hepatic injury significantly. Conclusion Aprotinin has protective functions on mice with acute liver injury in mice.

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What this paper is about

Objective To investigate the protective effect of aprotinin agaist acute hepatic injury in Mice. Methods The acute hepatic injury model of mice were induced by carbon tetrachloride(CCl_4). Measuring the changes of activity of serum ALT, AST and malondialdehyde(MDA) content of liver tissue, Observing the pathologic change of liver tissue. Results Aprotinin could decrease the activities of serum ALT, AST and the MAD content of liver tissue. Aprotinin could improve the pathologic change of liver tissue of acute hepatic injury significantly. Conclusion Aprotinin has protective functions on mice with acute liver injury in mice.

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Available abstract

Objective To investigate the protective effect of aprotinin agaist acute hepatic injury in Mice. Methods The acute hepatic injury model of mice were induced by carbon tetrachloride(CCl_4). Measuring the changes of activity of serum ALT, AST and malondialdehyde(MDA) content of liver tissue, Observing the pathologic change of liver tissue. Results Aprotinin could decrease the activities of serum ALT, AST and the MAD content of liver tissue. Aprotinin could improve the pathologic change of liver tissue of acute hepatic injury significantly. Conclusion Aprotinin has protective functions on mice with acute liver injury in mice.

Key concepts: Aprotinin, Liver tissue, Carbon tetrachloride, Medicine, Liver injury, Malondialdehyde, Pharmacology, Acute injury

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