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PRELIMINARY STUDY ON THE EXPRESSION OF SURVIVIN PROTEIN IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CARCINOMA

Xiao Wang

Abstract

Objective:To study the expression of survivin gene in cervical carcinoma and its relation to the pathogenesis of cervical carcinoma.Methods:Using SP immunohistochemical technique,we examined 74 cervical tissues of clinicopathological specimens,including 10 normal cervical tissues,5 cervical intraepithelial meoplasia(CIN)lesions,59 invasive squamous cell carcinomas.Rusults:Expression of survivin were not observed in normal cervical tissues. With the lesions progressing ,the expression rate of survivin protein had a increasing tendency.Expression of survivin was related to the tumor grade and clinical stage.Conclusion:The results suggested that survivin expression is the essential event in carcinogenesis and development of cervical carcinoma.Survivin expression in cervical carcinoma is a useful prognostic marker.

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Key concepts: Survivin, Immunohistochemistry, Cervical intraepithelial neoplasia, Medicine, Carcinogenesis, Cervical carcinoma, Cervical cancer, Stage (stratigraphy)