Inhibitory Effect of Triamcinolone Acetonide on Hypertrophic Scar and Oxygen Free Radicals in Rabbits

Objective To investigate the inhibitory effect of triamcinolone acetonide on hypertrophic scar and oxygen free radicals in rabbits.Methods Eighteen New Zealand rabbits were used.14 rabbits were selected randomly to construct animal models of hypertrophic scar on the ears.Another 4 rabbits(8 ears)were used as controls.6 weeks after operation,the hypertrophic scar on the ears were randomly divided to receive intra-lesion injection of TA(n=10),or normal saline(n=10),or nothing(n=8,sham group).9 weeks after operation,scar specimens were taken for scar thickness measurement,fibroblast counting under microscopy and MDA content detection by spectrophotometric method.Results ①3 weeks after TA treatment,the scar became very thin and soft with a similar color to normal skin and a smooth surface;②Histologic study showed the collagen fibers in TA group were reduced markedly and arranged parallelly;③Compared with normal skin,the fibroblast density-in,sham and saline groups increased significantly(P0.05),but the scar hypertrophic index was decreased dramatically in TA group(P0.05);④The MDA content was highest in TA group(P0.05),followed by that in sham and saline groups(P0.05),It was lowest in normal control group(P0.05).Conclusion The oxygen free radicals in the hypertrophic scar can be further increased by local injection of TA.