Influence of rennin-angiotensin system inhibitor on blood pressure, proteinuria and renal function of patients with chronic kidney disease

Objective To explore the influence of renin-angiotensin system inhibitor on blood pressure,proteinuria and renal function of patients with chronic kidney disease.Methods By prospective study,128 patients with chronic kidney disease were selected in our hospital from January 2012 to June 2013,which were randomly divided into group A,group B and group C.Group A(41 patients)was treated with Benner Pury,group B(42 patients)was given valsartan,and group C(45 patients)was given combination therapy by Benner Pury and valsartan.The blood pressure,24 h urine protein,Blood urea nitrogen(BUN),serum creatinine(SCr),creatinine clearance rate(Ccr)before and after treatment were observed.Results The systolic and diastolic blood pressure of the three groups after treatment were significantly lower than those before treatment(P0.05); 24 h urine protein and serum potassium of three groups after treatment were statistically different from those before treatment(P0.05); 24 h urinary protein of group C after treatment was(0.41±0.05)g,significantly lower than that of group A [(0.67±0.11)g] and group B [(0.64±0.08)g],P0.05; Scr,Ccr and BUN of three groups showed statistically significant difference before and after treatment(P0.05); After treatment,Scr and BUN of in group C were(71.69±3.32)μmol/L and(6.21±0.13)mmol/L,significantly lower than those of group A [(88.42±3.50)μmol/L,(8.19±0.17)mmol/L] and group B [(87.95±4.13)μmol/L,(7.92± 0.11)mmol/L],P0.05; Ccr of group C after treatment was(86.35±3.30)ml/min,significantly higher than that of group A [(76.33±3.55)ml/min] and group B [(75.87± 3.62)ml/min],P0.05.Conclusion Benner Pury and valsartan could reduce the body's blood pressure and urine protein,and had a good protective effect on the kidney.The combination of the two methods is a better treatment and can delay the progression of chronic kidney disease.