Itraconazole in hematopoietic stem cell transplantation for fungal infection caused by the application of two level prevention

OBJECTIVE To explore to itraconazole in hematopoietic stem cell transplantation(HSCT)fungal infection caused by two grade prevention in clinical application.METHODS From January 2007-June 2011,70 cases with malignant blood disease were collected in our hospital.All patients underwent allogeneic hematopoietic stem cell transplantation(Allo-HSCT),Patients with previous chemotherapy had invasive fungal infection(IFI)history.From July 2009 to June 2011,35 patients were collected as the observation group.After pretreatment for Allo-HSCT,when the neutrophil ﹤0.5×109/L or transplantation 0 days,itraconazole injection and oral liquid were sequential given to prevent fungal infection.Compared to historical controls,2007 January to 2009 June,35 patients with Allo-HSCT were given fluconazole tablets to prevent fungal infection one week before treatment,two groups were applied to prevent Allo-HSCT for 180 days.The fungal infection rate,mortality and adverse reaction of fungal infection were compared.RESULTS The fungal infection rate of observation group was 5.7%(2/35),the control group was 22.9%(8/35),there was significant difference between them(P﹤0.05);1 cases of the observation group died of fungal infection,the mortality rate of fungal infection control group was 17.1%(6/35),and there was significant difference between them(P﹤0.05);The incidence of adverse reactions of the control group was 8.6%(3/35),and was 17.2% for the observation group(6/35),there was significant difference between them(P﹥0.05).CONCLUSION Itraconazole can remarkably reduce the infection and mortality of IFI HSCT for patients with malignant blood disease caused by fungal.This method is safe and tolerability,which is worthy of two grade prevention application.