Effect of short course treatment of fluconazole and itraconazole in preventing invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation

Objective To compare the effeciency of fluconazole and itraconazole in preventing invasive fungal infection in patients after allogeneic hematopoietic stem cell transplantation.Methods 192 cases were divided into fluconazole group consisted of 134 patients and itraconazole group consisted of 58 patients.The occurrence and prognosis of invasive fungal infection between the two groups were compared.Results The incidence rates of invasive fungal infection in fluconazole and itraconazole group were respectively 9.0% and 5.2%,16.5% and 6.9%,17.2% and 8.7%,22% and 16.4% at 30days,60days,90days and 180days after transplantation(P=0.370,0.081,0.128 and 0.309,respectively).There are more side effects in patients given itraconazole.Conclusion Itraconazole appear to manifest certain superiority at 60 days after transplantation.