The observation of therapeutic efficacy of combination of benazepril and valsartan on the early stage diabetic nephropathy

OBJECTIVE To investigate the efficacy of monotherapy or combination of ACEI(benazepril)and ARB(valsartan dispersible tablets)in treating the early stage diabetic nephropathy(DN).METHODS 95 patients with early stage diabetic nephropa-thy(DN)were randomly allocated into there treatment groups:benazepril,valartan or the combination of these two drugs for 12 weeks.The changes of blood pressure,proteinuria,serum potassium and creatinine were observed before and after treatment.RESULTS Both of benazepril and valsartan reduced blood pressure(P0.01)and proteinuria(P0.05)efficiently.And their effects were similar.In contrast,the reduction in proteinuria was greater in combination therapy than in treatments of either drug alone(P0.01),but their reductions in blood pressure were achieved to the same level(P0.05).There were no significant differences in serum levels of potassium,creatinine and BUN before and after treatment(P0.05).CONCLUSION A combination of benazepril and valartan in patients with the early stage DN produces a better anti-proteinuric effect than either of the monotherapies.This protection is not dependent on changes in blood pressure.