Application of Multi-slice Helical Computed Tomography(MSCT) Perfusion to Renal Tumors and Its Relationship with Molecular Pathology

PurposeTo investigate the value of multi-slice helical computed tomography(MSCT) perfusion in diagnosis for renal tumors.MethodsFifty-nine cases with newly diagnosed renal tumor underwent perfusion imaging with MSCT.Renal blood volume(BV) ,blood flow(BF) ,permeability surface(PS) and mean transit time(MTT) were analyzed using perfusion 2 software.Expression of vascular endothelial growth factor(VEGF) and microvascular density(MVD) in renal tumor tissue and tumor surrounding tissue were examined.ResultsFifty-nine cases with renal tumor were pathologically proved,including 48 cases with renal cell carcinoma(RCC) ,6 cases with renal pelvic carcinoma(RPC) ,and 5 cases with renal agiomyolipoma(RAML) .The mean BF,BV and PS in different grade of RCC were lower than those of normal renal cortex(P0.01) ,and those in high grade RCC were significantly higher than those in low grade RCC(P0.01) .The perfusion parameters in RPC and RAML were significantly lower than those in RCC(P0.01) .The mean BF,BV and PS of RCC had significant positive correlation with expression of VEGF,and a significant negative correlation was observed between the mean MTT and expression of VEGF.Conclusion MSCT perfusion imaging is a functional imaging technique that is capable of quantitative assessment to tumor angiogenesis,blood perfusion and vascular permeability,and it also can provide information for staging of RCC.MSCT perfusion imaging is valuable for differential diagnosis of renal tumor.