The correlation of MSCT perfusion parameters with cell multiplication in renal cell carcinoma

Objective:To investigate the correlation of MSCT perfusion parameters with tumor Ki-67 antigen in RCC. Methods:The study included 24 cases of RCC proven histopathologically and 15 healthy volunteers as control. Target-slice dynamic enhanced scanning was performed by MSCT for all patients. Parameters including blood flow (BF),relative blood value (rBV),time to peak(TTP),permeability (Pm) and time-density curve (TDC) were analyzed using perfusion software. Ki-67 antigen expression was measured with immuno-histology chemistry technique (SP technique). The results were compared with MSCT perfusion imaging. Results:① There were significant differences for BF,rBVand Pm between different tumor cell grades,RCC and normal renal cortex. There was no significant association for TTP between different tumor cell grades,RCC and normal renal cortex; ② There were significant differences for Ki-67 antigen between different tumor cell grades; ③ CT perfusion parameters,including BF,rBV and Pm had significant correlations with Ki-67 antigen of lesions. TTP had no correlation with Ki-67 antigen of lesions. Conclusion:Blood flow perfusion and permeability of RCC can be quantitatively measured by MSCT perfusion imaging. MSCT perfusion provides useful information for pre-surgical staging and is a valuable means to assess tumor angiogenesis and cell multiplication,which is significant in the diagnosis and treatment of RCC.