Correlation Research of MSCT Perfusion Parameters with Angiogenesis,Cell Proliferation in Renal Cell Carcinoma

Objective To investigate the correlation of MSCT perfusion parameters with tumor microvessel density(MVD) and Ki 67 antigen in renal cell carcinoma(RCC).Materials and Methods The study included 24 cases of RCC proved histopathologically and 15 healthy volunteers as control.Target slice dynamic enhanced scanning was performed by MSCT for all patients.Parameters including blood flow(BF),relative blood value(rBV),time to peak(TTP),permeability(Pm) and time density curve(TDC) were analyzed using perfusion software.MVD and Ki 67 antigen expression were measured with immunohistology chemistry technique(SP technique).The results were compared with MSCT perfusion paraments.Results(1)There were significant differences for BF,rBVand Pm between different tumor cell grades,RCC and normal renal cortex.There was no significant correlation for TTP between different tumor cell grades,RCC and normal renal cortex.(2)There were significant differences for MVD and Ki 67 antigen between different tumor cell grades.(3)CT perfusion parameters,including BF,rBV and Pm had significant correlations with MVD and Ki 67 antigen of lesions.TTP had no correlation with MVD and Ki 67 antigen of lesions.Conclusion Blood flow perfusion and permeability of RCC could be quantitatively measured by MSCT perfusion imaging.MSCT perfusion provides important information of tumor angiogenesis and cell multiplication,which is useful to predict staging and treatment of RCC presurgery.