Clinical effect and safety observation of candesartan cilexetil in treating mild to moderate essential hypertension

Objective To observe the efficacy and safety of candesartan cilexetil in treating mild to moderate essential hypertension.Methods 90 cases were divided into treatment group and control group,45 cases of each.The treatment group received candesartan cilexetil,while the control group received valsartan.Both groups were treated for 8 weeks.Observed the effect of lowering pressure,changes of BP,HR,24h ambulatory blood pressure,T/P,as well as adverse reaction situation.Results The total effective rate of lowering pressure of the treatment group was 91.1%,while that of the control group was 88.9%,and there was no significant difference between them(P0.05).In both groups,compared with those before treatment,SBP and DBP of 2 weeks,4 weeks,6 weeks,8weeks after treatment were all reduced,and the differences were statistically significant(P0.05),but there was no significant difference between 2 groups(P0.05).After treatment,HR of the treatment groups was(74±6) times per minite,while that of the control group was(74±7) times per minite,and there was no significant difference(P0.05).Compared with those before treatment,24h,day and night BP of 2 groups were all lower,and the differences were statistically significant(P0.05),but there was no significant difference between 2 groups(P0.05).The T/P of SBP and DBP of the treatment group were 0.75,0.71 respectively,while those of the control group were 0.76,0.94 respectively.The adverse reaction of the treatment group was 8.9%,while that of the control group was 11.1%,and the difference was not statistically significant(P0.05).The adverse reaction was slight.Conclusion Treating mild to moderate essential hypertension with candesartan cilexetil is safe and effective,with good tolerance,which is worth clinical popularizing and application.