Treatment of 48 Cases of Mild to Moderate Essential Hypertention with Cetopril

Objective: To assess the therapeutic effectiveness and safety rate of cetopril in the treatment of essential hypertension. Methods: A double blind study was carried out in 96 patients with stage 1 and stage 2 essential hypertension. The patients were randomly divided into two groups, the treatment group and the control group. Patients of the treatment group and control group were given each 15 mg of cetopril and 12.5 mg of captopril PO b. i. d., respectively, for 8 consecutive weeks. Results: The effective rates in patients of the treatment group and control group were 89.0% and 80.0%, respectively, the difference being insignificant. In patients of both groups, the systolic blood pressure and diastolic blood pressure were lowered significantly beginning from the second week of the treatment, reached their nadir in the fourth week, and this effect was sustained up to the end of the study. The differences were insignificant between the heart rate and results of laboratory examinations before and after the treatment. Adverse reactions in patients of both groups were mild and tolerable. Conclusion: Cetopril was shown to be safe and effective in the treatment of mild to moderate essential hypertension, with only mild and tolerable adverse reactions.