Clinical effect of candesartan cilexetil in the treatment of essential hypertension

Objective To study the clinical effect of candesartan cilexetil in the treatment of mild to moderate essential hypertension.Methods In a randomized,single blind,parallel controlled trial,110 cases of patients with mild and moderate essential hypertension were randomly divided into treatment group and control group.The treatment group received candesartan cilexetil 8 mg oral 1 / d,while the control group was given valsartan 80 mg oral once daily for 8 weeks.Dose doubling was carried out for those with diastolic blood pressure≥12 kPa after 2 wk treatment.The antihypertensive effect and changes in amplitude and heart rate were compared between the 2 groups.Results The total effect rate of the treatment group was 90.9% and the control group was 87.3%,so there was no significant difference between 2 groups(P 0.05).A significant reduction of blood pressure(SBP or DBP) was achieved in both groups(P 0.01),but there was no significant difference between 2 groups(P 0.05).Before and after treatment,there was no significant changein heart rate,and there was no significant difference between 2 groups(P 0.05).Conclusion Candesartan cilexetil once daily is effective,safe and well tolerated in mild to moderate hypertension patients,which is worthy of clinical application.