Effect of Treating Acute Cerebral Infarction by Batroxobin Combined with Aspirin

Objective To investigate the effect and safety of Batroxobin(DF-521) combined with Asirin(ASA) in the treatment of acute cerebral infarction.Methods 93 patients with acute cerebral infarction who confirmed in hospital were randomly divided into 3 groups,platelet counts were measured before and after treatment,platelet aggregation,fibrinogen,high shear stress,hematocrit,thromboxaneB2(TXB2),the incidence of bleeding(including intracranial hemorrhage and other organs,bleeding) were all observed and statistical analysis were made.Results There was no significant difference between patient′s sex,age,body weight among ASA group(n=31),Batroxobin group(n=31) and ASA combined with Batroxobin group(n=31)(P0.05).After 1 week treatment,Platelet count,blood viscosity,platelet aggregation test(PAgT),fibrinogen,coagulation studies(PT,APTT,INR),TXB2 were not entire same in 3 groups.Platelet aggregation and fibrinogen in the mean pairwise comparison showed that the combination group was significantly lower than both platelet aggregation monotherapy group(P0.01);Batroxobin group and combined group was significantly lower than fibrinogen ASA group(P0.01).The incidence of bleeding among the 3 groups was not significant difference(P0.05).Conclusion ASA combined with Batroxobin shows better clinical effect and less hemorrhagic risk than ASA or Batroxobin in the therapy of acute cerebral infarction.