Application of platelet aggregation function detecting in aspirin thrombolytic therapy monitoring

Objective To evaluate the clinical value of platelet aggregation function detecting in hypertension complicated with cerebral infarction patients with aspirin thrombolysis therapy, and to investigate the correlation of aspirin resistance(AR) with cerebral infarction recrudescent. Methods 35 cases patients with hypertension Ⅲ combine cerebral infarction and 40 cases healthy controls in our hospital from January2013 to October 2014 were selected as subjects in the study. The platelet agglutination test of before and after medication of patients and control group were detected by America helena platelet aggregation analyzer. The results were analyzed statistically. Results There were no statistical significance in the differences of platelet aggregation rates between control group and patients group before taking aspirin after induced by arachidonic acid, adenosine diphosphate, collagen and epinephrine(t = 1.10,0.76,1.62,1.40, Pall 0.05). There were statistical significance in the differences of platelet aggregation rates between before and after taking aspirin after induced by arachidonic acid and epinephrine(t= 6.97,4.18, Pall 0.05). There were no statistical significance in the differences of platelet aggregation rates between before and after taking aspirin after induced by adenosine diphosphate and collagen(t= 1.70,1.31, Pall 0.05). There were 13 cases patients with AR, and22 cases without AR in 35 cases patients. The recurrence of cerebral infarction in patients with AR was 61.5%(8 / 13) which was higher than the recurrence of the patients without AR [9.1%(2 / 22)], and the difference had statistical significance(χ2= 11.01, P 0.05). There was correlation between recurrence of cerebral infarction and AR, and the correlation index was 0.88. Conclusion Platelet aggregation test can be used for monitoring the curative effect of aspirin in thrombolytic therapy. There is correlation between recurrence of cerebral infarction and AR.