Clinical Investigation on Treateating Arteriosclerotic Cerebral Infarction Combined with Hyperlipermia by Simvastatin

Objective To study the effect of simvastatin on the blood lipids level and prognosis in arteriosclerotic cerebral infarction associated with hyperlipermia patients.Methods 157 arteriosclerotic cerebral infarction combined with hyperlipermia patients were randomly divided in to 2 groups:79 cases in treated group prescribed with simvastatin 10mg/d for a course of 6 months and 78 cases in control group received placebo in the same manner.The follow-up study lasted for 1 years.Observe the changes in blood lipids and the occurrence of acute cardiocerebral vascular event.Results The level of TC,LDL and TG decreased and HDL increased significantly (P0.05),and the efficacy of treated group was superior to the control group obviously (P0.05).The results of follow-up study showed the recurrent number of cerebrovascular events in the treatment group were 30 times,and the control group were 50 times.Conclusion Simvastatin have curative effect affirmation to treat hyperlipemia with few side-effect.It should be extended to the clinical use in primary and secondary prevention of arteriosclerotic cerebral infarction combined with hyperlipermia.