Pharmacokinetics of enrofloxacin in Sebastodes fuscescens

In this article,Sebastodes fuscescens was treated orally with enrofloxacin(EF) via stomach tube at a single dose of 20 mg · kg-1 at 18 ℃.Concentration of the drugs in muscle and blood was determined by high performance liquid chromatography(HPLC).The concentration-time data were analyzed with DAS2.0.The results were as follows:the EF in muscle and blood concentration-time data were best described by two-compartment model;the absorption half-life time were 2.015 h and 2.173 h,the distribution half-life(t1/2α) were 3.267 h and 2.908 h,the elimination half-life(t1/2β) were 31.416 h and 23.675 h,the time of peak concentration(Tmax) was 4 h,the maximum EF concentration(Cmax) were 10.250 μg · mL-1 and 2.765 μg · mL-1.Ciprofloxacin(CF) and,the metabolite of enrofloxacin,can be detected in muscle and blood of Sebastodes fuscescens.The values of main pharmacokinetics parameters Ka,K,t1/2ka,t1/2,Tmax,Cmax were as follows:0.501 and 0.422 h-1,0.036 and 2.253 h-1,1.384 and 1.644 h,2.734 h and 1 927 h,4h and 6h,0.496 and 0.030 μg · mL-1.Base on those data,it was suggested that the consecutive days should be above 35 d at 18 ℃.