Studies on Pharmacokinetics and Residues of Sparfloxacin in Chickens

65 of 30-day-old healthy chickens were selected to study pharmacokinetics and residues of Sparfloxacin by HPLC. The results obtained showed that the blood concentration-time curves after oral administration were best described by a two compartment open model. The main pharmacokinetic parameters were as follows: t1/2α0.958 5 h, t1/2β11.745 h, tmax0.651 4 h, Cmax0.527 1 μg/ml, AUC1.790 8 mg/L/h. The kidney and heart concentration-time curves fitted the biexponential equation with first order absorption. Their main pharmacokinetics parameters were t1/2Ka0.373 3 h, 0.153 0h; t1/2K1.300 7 h, 2.101 3 h; tmax1.042 0h, 0.623 9 h; Cmax2.110 4 μg/ml, 1.672 1 μg/ml; AUC6.576 4 mg/L/h, 6.228 6 mg/L/h. And the liver, lung and muscle concentration-time data were best described by a triexponential equation with the first order absorption. The main pharamacokinetics parameters were as follows: t1/2α0.367 2 h, 0.615 6 h, 1.583 5 h; t1/2β3.999 8 h, 15.027 1 h, 2.010 3 h; tmax0.745 8 h, 0.732 2 h, 1.372 6 h; Cmax4.470 9 μg/ml, 2.526 7 μg/ml, 0.976 0 μg/ml, AUC20.893 mg/L/h, 27.242 mg/L/h, 9.794 3 mg/L/h, respectively. The withdrawal time of Sparfloxacin in chickens were suggested as 7 days.