Expression and clinical significance of Bcl-2,ER,PR and C-erbB-2 in breast cancer

OBJECTIVE To explore the relationship between expression of Bcl-2,ER,PR,C-erbB-2 and biological behavior in breast cancer.METHODS The expression of Bcl-2,ER,PR and C-erbB-2 was determined by immunohistochemical SP methods in 131 cases of breast cancer.RESULTS The positive expression rates of Bcl-2,ER,PR and C-erbB-2 in 131 cases of breast cancer were 84.7%,50.4%, 58.8%and 46.6%,respectively.The expression of Bcl-2 protein was obviously positive correlation with expression of ER and PR,but there was no correlation with C-erbB-2 protein and lymph nodes metastasis.The expression rate of Bcl-2 was no significant difference between the invasive ductal carcinoma and in situ carcinoma,but it was lower in medullary carcinoma.Combination positive rates of ER and PR were 76.9%,59.8%and 21.4%on in situ carcinoma,invasive ductal carcinoma and medullary carcinoma, respectively,and the differences were significant.The expression rate of C-erbB-2 was 61.5%,45.7%and 35.7%on in situ carcinoma,invasive ductal carcinoma and medullary carcinoma,respectively,and the differences were significant too.The negative expression of Bcl-2 in breast cancer,there was negative correlation between the expression of C-erbB-2 and expression of ER and PR.CONCLUSION Combined detection of the expression of Bcl-2,ER,PR,and C-erbB-2 is helpful to evaluate the biological behavior and prognosis of breast cancer,and it is also helpful to select the individual chemotherapy protocol for patientwith breast cancer after operation.